RFX5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
RFX5 polycolnal antibody (Cat # PAB27612) (2ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of RFX5.
Immunogen
A synthetic peptide corresponding to human RFX5.
Sequence
TGDKSSEPSTLSNE
Host
Goat
Theoretical MW (kDa)
70
Reactivity
Chicken, Dog, Human, Mouse, Pig, Rabbit, Rat
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:1000)
Western Blot (1-3ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
RFX5 polycolnal antibody (Cat # PAB27612) (2ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. -
Gene Info — RFX5
Entrez GeneID
5993Protein Accession#
NP_000440.1Gene Name
RFX5
Gene Alias
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Gene Description
regulatory factor X, 5 (influences HLA class II expression)
Gene Ontology
HyperlinkGene Summary
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq
Other Designations
OTTHUMP00000082795|OTTHUMP00000196318|regulatory factor X, 5
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Interactome
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Pathway
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Disease
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