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Last updated: 2017/12/10

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CMA1 polyclonal antibody

  • Catalog # : PAB27585
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against synthetic peptide of CMA1.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human CMA1.
  • Sequence:
  • QFRHPKYNTSTLHHD
  • Host:
  • Goat
  • Theoretical MW (kDa):
  • 35
  • Reactivity:
  • Human
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 0.5 mg/mL
  • Recommend Usage:
  • ELISA (1:32000)
    Western Blot (0.5-2ug/ml)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • HEK293 lysate (10ug protein in RIPA buffer) over expressing human CMA1 with DYKDDDDK tag probed with CMA1 polycolnal antibody (Cat # PAB27585) (0.5ug/ml) in Lane 1 and probed with anti- DYKDDDDK Tag (1/3000) in Lane 3.
    Lane 2: Mock-transfected HEK293 probed with CMA1 polycolnal antibody (Cat # PAB27585) (1mg/ml). Primary incubations were for 1 hour. Detected by chemiluminescence.
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1215
  • Gene Name:
  • CMA1
  • Gene Alias:
  • CYH,MCT1,MGC119890,MGC119891,chymase
  • Gene Description:
  • chymase 1, mast cell
  • Gene Summary:
  • This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq
  • Other Designations:
  • chymase 1 preproprotein transcript E,chymase 1 preproprotein transcript I,chymase, heart,chymase, mast cell,mast cell protease I
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