CMA1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of CMA1.
Immunogen
A synthetic peptide corresponding to internal region of human CMA1.
Sequence
QFRHPKYNTSTLHHD
Host
Goat
Theoretical MW (kDa)
35
Reactivity
Human
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-2ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 lysate (10ug protein in RIPA buffer) over expressing human CMA1 with DYKDDDDK tag probed with CMA1 polycolnal antibody (Cat # PAB27585) (0.5ug/ml) in Lane 1 and probed with anti- DYKDDDDK Tag (1/3000) in Lane 3.
Lane 2: Mock-transfected HEK293 probed with CMA1 polycolnal antibody (Cat # PAB27585) (1mg/ml). Primary incubations were for 1 hour. Detected by chemiluminescence. -
Gene Info — CMA1
Entrez GeneID
1215Protein Accession#
NP_001827.1Gene Name
CMA1
Gene Alias
CYH, MCT1, MGC119890, MGC119891, chymase
Gene Description
chymase 1, mast cell
Omim ID
118938Gene Ontology
HyperlinkGene Summary
This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq
Other Designations
chymase 1 preproprotein transcript E|chymase 1 preproprotein transcript I|chymase, heart|chymase, mast cell|mast cell protease I
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Interactome
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Pathway
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Disease
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