UMOD polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
UMOD polycolnal antibody (Cat # PAB27542) (0.5ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of UMOD.
Immunogen
A synthetic peptide corresponding to amino acids 525-536 at internal region of human UMOD.
Sequence
DRCPHTRDSTIQ
Host
Goat
Theoretical MW (kDa)
80
Reactivity
Human
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:128000)
Western Blot (0.3-1ug/ml)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
UMOD polycolnal antibody (Cat # PAB27542) (0.5ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. -
Gene Info — UMOD
Entrez GeneID
7369Protein Accession#
NP_003352.2Gene Name
UMOD
Gene Alias
ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP
Gene Description
uromodulin
Gene Ontology
HyperlinkGene Summary
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq
Other Designations
OTTHUMP00000162212|Tamm-Horsfall glycoprotein|uromodulin (uromucoid, Tamm-Horsfall glycoprotein)|uromucoid
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Interactome
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Disease
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