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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunohistochemical staining of human duodenum with CDC2L2 polyclonal antibody (Cat # PAB27486) shows strong nuclear positivity in glandular cells.

Immunofluorescence

Immunofluorescent staining of human cell line U-251MG with CDC2L2 polyclonal antibody (Cat # PAB27486) at 1-4 ug/mL dilutions shows positivity in nucleus and cytoplasm.

Entrez GeneID

728642

Gene Name

CDC2L2

Gene Alias

CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, MGC131975, PITSLRE, p58GTA

Gene Description

cell division cycle 2-like 2 (PITSLRE proteins)

Omim ID

116951

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq

Other Designations

PITSLRE B|PITSLRE protein kinase beta|PITSLRE serine/threonine-protein kinase CDC2L2|cell division cycle 2-like 2|cell division cycle 2-like protein kinase 2|galactosyltransferase-associated protein kinase p58/GTA