FGFR3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FGFR3.
Immunogen
A synthetic peptide corresponding to 19 amino acids at C-terminus of human FGFR3.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
FGFR3 antibody is human, mouse and rat reactive. At least three isoforms of FGFR3 are known to exist; this antibody will detect all three.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for up to one year.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of FGFR3 in SK-N-SH cell lysate with FGFR3 polyclonal antibody (Cat # PAB27450) at (lane 1) 0.5 and (lane 2) 1 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — FGFR3
Entrez GeneID
2261Protein Accession#
NP_001156685Gene Name
FGFR3
Gene Alias
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Gene Description
fibroblast growth factor receptor 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000149959|achondroplasia, thanatophoric dwarfism|hydroxyaryl-protein kinase|tyrosine kinase JTK4
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Interactome
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Disease
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