Rabbit polyclonal antibody raised against synthetic peptide of CARD10.
A synthetic peptide corresponding to 16 amino acids at N-terminus of human CARD10.
CARD10 antibody is human specific. At least three isoforms of CARD10 are known to exist; this antibody will only detect isoform 1. CARD10 antibody is predicted not to cross-react with other CARMA proteins.
Peptide affinity purification
Immunohistochemistry (5 ug/mL) The optimal working dilution should be determined by the end user.
In PBS (0.02% sodium azide)
Store at 4°C for three months. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM
Bcl10 binding protein and activator of NFKB,CARD-containing MAGUK 3 protein,caspase recruitment domain protein 10