CARD14 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CARD14.
Immunogen
A synthetic peptide corresponding to 14 amino acids at C-terminus of human CARD14.
Host
Rabbit
Reactivity
Human
Specificity
CARD14 antibody is human specific. At least three isoforms of CARD14 are known to exist; this antibody will only detect isoform 1. CARD14 antibody is predicted not to cross-react with other CARMA proteins.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry analysis of CARD14 in human placenta tissue with CARD14 polyclonal antibody (Cat # PAB27180) at 5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CARD14
Entrez GeneID
79092Protein Accession#
NP_007715Gene Name
CARD14
Gene Alias
BIMP2, CARMA2
Gene Description
caspase recruitment domain family, member 14
Omim ID
607211Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
CARD-containing MAGUK 2 protein|bcl10-interacting maguk protein 2|card-maguk protein 2|caspase recruitment domain protein 14
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Interactome
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Disease
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