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CARD14 polyclonal antibody

  • Catalog # : PAB27180
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CARD14.
  • Immunogen:
  • A synthetic peptide corresponding to 14 amino acids at C-terminus of human CARD14.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • CARD14 antibody is human specific. At least three isoforms of CARD14 are known to exist; this antibody will only detect isoform 1. CARD14 antibody is predicted not to cross-react with other CARMA proteins.
  • Form:
  • Liquid
  • Purification:
  • Peptide affinity purification
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemistry analysis of CARD14 in human placenta tissue with CARD14 polyclonal antibody (Cat # PAB27180) at 5 ug/mL.
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Gene Name:
  • CARD14
  • Gene Alias:
  • BIMP2,CARMA2
  • Gene Description:
  • caspase recruitment domain family, member 14
  • Gene Summary:
  • The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • CARD-containing MAGUK 2 protein,bcl10-interacting maguk protein 2,card-maguk protein 2,caspase recruitment domain protein 14
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