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TOP2B polyclonal antibody

  • Catalog # : PAB27101
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of TOP2B.
  • Immunogen:
  • A synthetic peptide corresponding to human TOP2B.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 183
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • TOP2B polyclonal antibody detects endogenous levels of TOP2B protein.
  • Form:
  • Liquid
  • Purification:
  • Antigen affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    Immunohistochemistry (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.2 (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of Jurkat cell lysate with TOP2B polyclonal antibody (Cat # PAB27101).
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human lung cancer tissue using TOP2B polyclonal antibody (Cat # PAB27101).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 7155
  • Gene Name:
  • TOP2B
  • Gene Alias:
  • TOPIIB,top2beta
  • Gene Description:
  • topoisomerase (DNA) II beta 180kDa
  • Gene Summary:
  • This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq
  • Other Designations:
  • DNA topoisomerase II beta,DNA topoisomerase II, 180 kD,DNA topoisomerase II, beta isozyme,U937 associated antigen,antigen MLAA-44,topo II beta,topoisomerase (DNA) II beta (180kD),topoisomerase II beta,topoisomerase IIb
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