MKNK1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MKNK1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human MKNK1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The MKNK1 polyclonal antibody (Cat # PAB2708) is used in Western blot to detect MKNK1 in A2058 cell lysate. -
Gene Info — MKNK1
Entrez GeneID
8569Protein Accession#
NP_003675;Q9BUB5Gene Name
MKNK1
Gene Alias
MNK1
Gene Description
MAP kinase interacting serine/threonine kinase 1
Omim ID
606724Gene Ontology
HyperlinkOther Designations
MAP kinase interacting kinase 1|MAP kinase-interacting serine/threonine kinase 1|OTTHUMP00000009674
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Interactome
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Pathway
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Disease
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Publication Reference
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Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Korneeva NL, Rhoads RE, Sonenberg N, Traugh JA.
The Journal of Biological Chemistry 2004 Jul; 279(37):38649.
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Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.
Cuesta R, Xi Q, Schneider RJ.
Journal of Virology 2004 Jul; 78(14):7707.
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Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.
Knauf U, Tschopp C, Gram H.
Molecular and Cellular Biology 2001 Aug; 21(16):5500.
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Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.
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