ACTA1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of ACTA1 polyclonal antibody (Cat # PAB27014) in extracts from LoVo cells.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of ACTA1 polyclonal antibody (Cat # PAB27014) in paraffin-embedded human muscle tissue.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ACTA1.
Immunogen
A synthetic peptide corresponding to human ACTA1.
Host
Rabbit
Theoretical MW (kDa)
45
Reactivity
Chicken, Human, Mouse, Pig, Rat
Specificity
ACTA1 polyclonal antibody detects endogenous levels of ACTA1 protein.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ACTA1 polyclonal antibody (Cat # PAB27014) in extracts from LoVo cells.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of ACTA1 polyclonal antibody (Cat # PAB27014) in paraffin-embedded human muscle tissue.Enzyme-linked Immunoabsorbent Assay
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Gene Info — ACTA1
Entrez GeneID
58Protein Accession#
P68133Gene Name
ACTA1
Gene Alias
ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3
Gene Description
actin, alpha 1, skeletal muscle
Gene Ontology
HyperlinkGene Summary
The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq
Other Designations
OTTHUMP00000036123|alpha skeletal muscle actin
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Interactome
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Disease
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Publication Reference
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Reversal of Sp1 transactivation and TGFβ1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation.
Racine M, Fu M, Shuang T, Zhang Y, Pei Y, Wu L, Wang R, Yang G.
Toxicology and Applied Pharmacology 2018 Oct; 356:25.
Application：WB-Ce, Human, Fibroblast cells.
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Reversal of Sp1 transactivation and TGFβ1/SMAD1 signaling by H2S prevent nickel-induced fibroblast activation.
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