Products

Western Blot (Cell lysate)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

Immunofluorescence

Entrez GeneID

Protein Accession#

Gene Name

MAPK8IP3

Gene Alias

DKFZp762N1113, FLJ00027, JIP3, JSAP1, KIAA1066, SYD2

Gene Description

mitogen-activated protein kinase 8 interacting protein 3

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq

Other Designations

C-jun-amino-terminal kinase interacting protein 3|JNK-interacting protein 3|JNK/SAPK-associated protein-1|JNK/stress-activated protein kinase-associated protein 1|OTTHUMP00000158803|homolog of Drosophila Sunday driver 2