KCNJ11 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KCNJ11.
Immunogen
A synthetic peptide corresponding to human KCNJ11.
Host
Rabbit
Theoretical MW (kDa)
40
Reactivity
Human, Mouse
Specificity
KCNJ11 polyclonal antibody detects endogenous levels of KCNJ11 protein.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HeLa cell lysate with KCNJ11 polyclonal antibody (Cat # PAB26936).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using KCNJ11 polyclonal antibody (Cat # PAB26936).Immunofluorescence
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Gene Info — KCNJ11
Entrez GeneID
3767Protein Accession#
Q14654Gene Name
KCNJ11
Gene Alias
BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3
Gene Description
potassium inwardly-rectifying channel, subfamily J, member 11
Gene Ontology
HyperlinkGene Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). [provided by RefSeq
Other Designations
ATP-sensitive inward rectifier potassium channel 11|beta-cell inward rectifier subunit|inwardly rectifying potassium channel KIR6.2|potassium inwardly-rectifying channel J11
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Interactome
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