TNFSF12 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of COLO 205 cell lysate with TNFSF12 polyclonal antibody (Cat # PAB26913).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using TNFSF12 polyclonal antibody (Cat # PAB26913).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TNFSF12.
Immunogen
A synthetic peptide corresponding to human TNFSF12.
Host
Rabbit
Theoretical MW (kDa)
27
Reactivity
Human, Mouse
Specificity
TNFSF12 polyclonal antibody detects endogenous levels of TNFSF12 protein.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of COLO 205 cell lysate with TNFSF12 polyclonal antibody (Cat # PAB26913).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human brain tissue using TNFSF12 polyclonal antibody (Cat # PAB26913).Immunofluorescence
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Gene Info — TNFSF12
Entrez GeneID
8742Protein Accession#
O43508Gene Name
TNFSF12
Gene Alias
APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Gene Description
tumor necrosis factor (ligand) superfamily, member 12
Omim ID
602695Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq
Other Designations
APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis
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Interactome
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Pathway
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Disease
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