MAP3K3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate with MAP3K3 polyclonal antibody (Cat # PAB26874).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MAP3K3.
Immunogen
A synthetic peptide corresponding to human MAP3K3.
Host
Rabbit
Theoretical MW (kDa)
71
Reactivity
Human, Mouse
Specificity
MAP3K3 polyclonal antibody detects endogenous levels of MAP3K3 protein.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of HepG2 cell lysate with MAP3K3 polyclonal antibody (Cat # PAB26874).Immunohistochemistry
Immunofluorescence
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Gene Info — MAP3K3
Entrez GeneID
4215Protein Accession#
Q99759Gene Name
MAP3K3
Gene Alias
MAPKKK3, MEKK3
Gene Description
mitogen-activated protein kinase kinase kinase 3
Omim ID
602539Gene Ontology
HyperlinkGene Summary
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
MAP/ERK kinase kinase 3|MAPK/ERK kinase kinase 3
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Interactome
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Pathway
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Disease
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