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PLCG1 polyclonal antibody

  • Catalog # : PAB26700
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PLCG1.
  • Immunogen:
  • A synthetic peptide corresponding to residues surrounding Y783 of human PLCG1.
  • Sequence:
  • G-F-Yp-V-E
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity chromatography
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1:500-1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of exreacts from A-431 cells untreated or treated with EGF (200 ng/mL, 10 min) using PLCG1 polyclonal antibody (Cat # PAB26700).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5335
  • Gene Name:
  • PLCG1
  • Gene Alias:
  • PLC-II,PLC1,PLC148,PLCgamma1
  • Gene Description:
  • phospholipase C, gamma 1
  • Gene Summary:
  • The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate,1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1,OTTHUMP00000031787,OTTHUMP00000178982,PLC-gamma-1,inositoltrisphosphohydrolase,monophosphatidylinositol phosphodiesterase,phosphatidylinositol
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