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LPHN1 polyclonal antibody

  • Catalog # : PAB26533
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of LPHN1.
  • Immunogen:
  • A synthetic peptide corresponding to 16 amino acids at C-terminus of human LPHN1.
  • Host:
  • Rabbit
  • Reactivity:
  • Hamster, Human, Monkey, Mouse, Rat
  • Specificity:
  • BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NOL6 (50%).
  • Form:
  • Liquid
  • Purification:
  • Immunoaffinity chromatography
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human brain, neurons and glia with LPHN1 polyclonal antibody (Cat # PAB26533). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Gene Name:
  • LPHN1
  • Gene Alias:
  • CIRL1,CL1,LEC2
  • Gene Description:
  • latrophilin 1
  • Gene Summary:
  • This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms
  • Other Designations:
  • calcium-independent alpha-latrotoxin receptor 1,lectomedin-2
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