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GRM2 polyclonal antibody

  • Catalog # : PAB26519
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of GRM2.
  • Immunogen:
  • A synthetic peptide corresponding to 19 amino acids at N-terminal extracellular domain of human GRM2.
  • Host:
  • Rabbit
  • Reactivity:
  • Bovine, Dog, Hamster, Human, Mouse, Pig, Rabbit, Rat
  • Specificity:
  • BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM3 (42%).
  • Form:
  • Liquid
  • Purification:
  • Immunoaffinity chromatography
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5-10 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human brain, neurons and glia with GRM2 polyclonal antibody (Cat # PAB26519). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
  • Immunocytochemistry
  • Application Image
  • Western Blot
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Immunocytochemistry
  • Gene Information
  • Entrez GeneID:
  • 2912
  • Gene Name:
  • GRM2
  • Gene Alias:
  • Gene Description:
  • glutamate receptor, metabotropic 2
  • Gene Summary:
  • L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • glutamate metabotropic receptor 2,glutamate receptor homolog
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