GRM6 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRM6.
Immunogen
A synthetic peptide corresponding to N-terminus of human GRM6.
Host
Rabbit
Reactivity
Bovine, Dog, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except GRM7 (73%), GRM4 (67%).
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (12 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human eye, retina with GRM6 polyclonal antibody (Cat # PAB26500). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. -
Gene Info — GRM6
Entrez GeneID
2916Protein Accession#
O15303Gene Name
GRM6
Gene Alias
CSNB1B, DKFZp686H1993, GPRC1F, MGLUR6, mGlu6
Gene Description
glutamate receptor, metabotropic 6
Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq
Other Designations
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Publication Reference
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CRIP1a inhibits endocytosis of G-protein coupled receptors activated by endocannabinoids and glutamate by a common molecular mechanism.
Mascia F, Klotz L, Lerch J, Ahmed MA, Zhang Y, Enz R.
Journal of Neurochemistry 2017 Mar; 141(4):577.
Application:Func, Human, HEK 293 cells.
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CRIP1a inhibits endocytosis of G-protein coupled receptors activated by endocannabinoids and glutamate by a common molecular mechanism.
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