GRM3 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human brain, coroid plexus with GRM3 polyclonal antibody (Cat # PAB26398). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunocytochemistry
Immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected (A) or untransfected (B) with GRM3. Using GRM3 polyclonal antibody (Cat # PAB26398).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRM3.
Immunogen
A synthetic peptide corresponding to 16 amino acids at N-terminal extracellular domain of human GRM3.
Host
Rabbit
Reactivity
Bovine, Horse, Human, Monkey, Pig
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (38 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical (Formalin/PFA-fixed paraffin-embedded sections) staining in human brain, coroid plexus with GRM3 polyclonal antibody (Cat # PAB26398). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.Immunocytochemistry
Immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected (A) or untransfected (B) with GRM3. Using GRM3 polyclonal antibody (Cat # PAB26398). -
Gene Info — GRM3
Entrez GeneID
2913Protein Accession#
Q14832Gene Name
GRM3
Gene Alias
GLUR3, GPRC1C, MGLUR3, mGlu3
Gene Description
glutamate receptor, metabotropic 3
Omim ID
601115Gene Ontology
HyperlinkGene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq
Other Designations
glutamate metabotropic receptor 3
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Interactome
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