Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human breast cancer tissue with GPER polyclonal antibody (Cat # PAB26364). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq
G protein-coupled receptor 30,IL8-related receptor,OTTHUMP00000115502,chemokine receptor-like 2,constitutively expressed peptide-like receptor,flow-induced endothelial G-protein coupled receptor,heptahelix receptor,leucine rich protein in GPR30 3'UTR