LRRK2 polyclonal antibody
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More Files
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Immunofluorescence
Tau-stable SH-SY5Y cell image stained for endogenous LRRK2 (green) by L955a affinity purified, phosphorylated tau (red, monoclonal AT8) and nuclear staining by DAPI.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of LRRK2.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding L955 of human LRRK2.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunofluorescence
Tau-stable SH-SY5Y cell image stained for endogenous LRRK2 (green) by L955a affinity purified, phosphorylated tau (red, monoclonal AT8) and nuclear staining by DAPI. -
Gene Info — LRRK2
Entrez GeneID
120892Protein Accession#
XP_058513Gene Name
LRRK2
Gene Alias
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Description
leucine-rich repeat kinase 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq
Other Designations
Parkinson disease (autosomal dominant) 8|augmented in rheumatoid arthritis 17
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Interactome
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Disease
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Publication Reference
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Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
Biskup S, Moore DJ, Rea A, Lorenz-Deperieux B, Coombes CE, Dawson VL, Dawson TM, West AB.
BMC Neuroscience 2007 Nov; 8:102.
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Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
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