Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human brain, neurons and glia with DRD2 polyclonal antibody (Cat # PAB26232). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq