EDNRB polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human adrenal medulla tissue with EDNRB polyclonal antibody (Cat # PAB26220). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunocytochemistry
Immunocytochemical anyalysis of FZD9 in 293 cell lysate with FZD9 polyclonal antibody (Cat # PAB26220).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of EDNRB.
Immunogen
A synthetic peptide corresponding to 19 amino acid at N-terminus of human EDNRB.
Host
Rabbit
Reactivity
Dog, Human
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (4-11 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human adrenal medulla tissue with EDNRB polyclonal antibody (Cat # PAB26220). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.Immunocytochemistry
Immunocytochemical anyalysis of FZD9 in 293 cell lysate with FZD9 polyclonal antibody (Cat # PAB26220). -
Gene Info — EDNRB
Entrez GeneID
1910Protein Accession#
P24530Gene Name
EDNRB
Gene Alias
ABCDS, ETB, ETBR, ETRB, HSCR, HSCR2
Gene Description
endothelin receptor type B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq
Other Designations
OTTHUMP00000178736|endothelin receptor non-selective type
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Interactome
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Pathway
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Disease
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