FZD6 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human pancreas tissue with FZD6 polyclonal antibody (Cat # PAB26210). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunocytochemistry
Immunocytochemical anyalysis of FZD6 in 293 cell lysate with FZD6 polyclonal antibody (Cat # PAB26210).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of FZD6.
Immunogen
A synthetic peptide corresponding to 16 amino acid at N-terminus of human FZD6.
Host
Rabbit
Reactivity
Human, Monkey
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD3 (50%).
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (6-14 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human pancreas tissue with FZD6 polyclonal antibody (Cat # PAB26210). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.Immunocytochemistry
Immunocytochemical anyalysis of FZD6 in 293 cell lysate with FZD6 polyclonal antibody (Cat # PAB26210). -
Gene Info — FZD6
Entrez GeneID
8323Protein Accession#
O60353Gene Name
FZD6
Gene Alias
Hfz6
Gene Description
frizzled homolog 6 (Drosophila)
Omim ID
603409Gene Ontology
HyperlinkGene Summary
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
frizzled 6|seven transmembrane helix receptor
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Interactome
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Pathway
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Disease
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