NEK8 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NEK8.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human NEK8.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The NEK8 polyclonal antibody (Cat # PAB2619) is used in Western blot to detect NEK8 in A2058 cell lysate -
Gene Info — NEK8
Entrez GeneID
284086Protein Accession#
NP_835464;Q86SG6Gene Name
NEK8
Gene Alias
JCK, MGC138445, NEK12A
Gene Description
NIMA (never in mitosis gene a)- related kinase 8
Omim ID
609799Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq
Other Designations
NIMA-family kinase NEK8|NIMA-related kinase 12a|NIMA-related kinase 8|serine/thrionine-protein kinase NEK8
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Interactome
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Publication Reference
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Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice.
Valkova N, Yunis R, Mak SK, Kang K, Kultz D.
Molecular & Cellular Proteomics 2005 Jul; 4(7):1009.
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Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.
Bowers AJ, Boylan JF.
Gene 2004 Mar; 328:135.
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Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2.
Holland PM, Milne A, Garka K, Johnson RS, Willis C, Sims JE, Rauch CT, Bird TA, Virca GD.
The Journal of Biological Chemistry 2002 May; 277(18):16229.
Application:IF, WB-Ce, WB-Tr, Human, HeLa, HT29 cells.
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Nek8 mutation causes overexpression of galectin-1, sorcin, and vimentin and accumulation of the major urinary protein in renal cysts of jck mice.
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