Immunohistochemical staining of human brain, cerebellum with SCN1A polyclonal antibody (Cat # PAB26052). Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders
febrile convulsions 3,sodium channel protein, brain I alpha subunit,sodium channel, voltage-gated, type I, alpha,sodium channel, voltage-gated, type I, alpha polypeptide