SLC16A1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SLC16A1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human SLC16A1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of SLC16A1 polyclonal antibody (Cat # PAB2599) in HL-60 cell line lysates (35 ug/lane).SLC16A1 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — SLC16A1
Entrez GeneID
6566Protein Accession#
NP_003042;P53985Gene Name
SLC16A1
Gene Alias
FLJ36745, HHF7, MCT, MCT1, MGC44475
Gene Description
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Gene Ontology
HyperlinkGene Summary
The SLC16A1 gene encodes a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes Import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT (Garcia et al., 1994 [PubMed 8124722]).[supplied by OMIM
Other Designations
OTTHUMP00000013960|monocarboxylate transporter 1|solute carrier family 16 (monocarboxylic acid transporters), member 1|solute carrier family 16, member 1
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Interactome
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Disease
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Publication Reference
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Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.
Pinheiro C, Longatto-Filho A, Scapulatempo C, Ferreira L, Martins S, Pellerin L, Rodrigues M, Alves VA, Schmitt F, Baltazar F.
Virchows Archiv: an International Journal of Pathology 2008 Feb; 452(2):139.
Application:IHC-P, WB-Ti, Human, Human colorectal carcinomas.
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Physical exercise-induced hypoglycemia caused by failed silencing of monocarboxylate transporter 1 in pancreatic beta cells.
Otonkoski T, Jiao H, Kaminen-Ahola N, Tapia-Paez I, Ullah MS, Parton LE, Schuit F, Quintens R, Sipila I, Mayatepek E, Meissner T, Halestrap AP, Rutter GA, Kere J.
American Journal of Human Genetics 2007 Sep; 81(3):467.
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Monocarboxylate transporter 1 mediates DL-2-Hydroxy-(4-methylthio)butanoic acid transport across the apical membrane of Caco-2 cell monolayers.
Martin-Venegas R, Rodriguez-Lagunas MJ, Geraert PA, Ferrer R.
The Journal of Nutrition 2007 Jan; 137(1):49.
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Increased expression of monocarboxylate transporters 1, 2, and 4 in colorectal carcinomas.
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