OPRS1 polyclonal antibody
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More Files
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Western Blot (Transfected lysate)
Western blot analysis of OPRS1 (arrow) using rabbit OPRS1 polyclonal antibody (Cat # PAB2593). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies).
Flow Cytometry
Flow cytometric analysis of NCI-H292 cells using OPRS1 polyclonal antibody (Cat # PAB2593)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of OPRS1.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human OPRS1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of OPRS1 (arrow) using rabbit OPRS1 polyclonal antibody (Cat # PAB2593). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the OPRS1 gene (Lane 2) (Origene Technologies).Flow Cytometry
Flow cytometric analysis of NCI-H292 cells using OPRS1 polyclonal antibody (Cat # PAB2593)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Gene Info — SIGMAR1
Entrez GeneID
10280Protein Accession#
NP_005857;Q99720Gene Name
SIGMAR1
Gene Alias
FLJ25585, MGC3851, OPRS1, SR-BP1
Gene Description
sigma non-opioid intracellular receptor 1
Omim ID
601978Gene Ontology
HyperlinkGene Summary
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000000515|OTTHUMP00000000516|OTTHUMP00000000517|OTTHUMP00000021286|SR31747 binding protein 1|aging-associated gene 8 protein|opioid receptor, sigma 1|sigma1 receptor|type I sigma receptor
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Interactome
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Disease
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Publication Reference
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An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.
Lee IT, Chen S, Schetz JA.
European Journal of Pharmacology 2008 Jan; 578(2-3):123.
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Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells.
Cobos EJ, del Pozo E, Baeyens JM.
Journal of Neurochemistry 2007 Aug; 102(3):812.
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Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.
Maurice T, Gregoire C, Espallergues J.
Pharmacology, Biochemistry, and Behavior 2006 Aug; 84(4):581.
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An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.
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