CBL (phospho Y700) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CBL (phospho Y700) polyclonal antibody (Cat # PAB25918).
Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using CBL (phospho Y700) polyclonal antibody (Cat # PAB25918, red).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CBL.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y700 of human CBL.
Sequence
T-E-Yp-M-T
Host
Rabbit
Theoretical MW (kDa)
120
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CBL (phospho Y700) polyclonal antibody (Cat # PAB25918).Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using CBL (phospho Y700) polyclonal antibody (Cat # PAB25918, red). -
Gene Info — CBL
Entrez GeneID
867Protein Accession#
P22681Gene Name
CBL
Gene Alias
C-CBL, CBL2, RNF55
Gene Description
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Omim ID
165360Gene Ontology
HyperlinkGene Summary
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
Other Designations
oncogene CBL2
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Interactome
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