EIF2S1 (phospho S49) polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EIF2S1 (phospho S49) polyclonal antibody (Cat # PAB25902).
Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using EIF2S1 (phospho S49) polyclonal antibody (Cat # PAB25902, red).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of EIF2S1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S49 of human EIF2S1.
Sequence
L-L-Sp-E-L
Host
Rabbit
Theoretical MW (kDa)
38
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:100-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EIF2S1 (phospho S49) polyclonal antibody (Cat # PAB25902).Immunofluorescence
Immunofluorescence staining of methanol-fixed HeLa cells using EIF2S1 (phospho S49) polyclonal antibody (Cat # PAB25902, red). -
Gene Info — EIF2S1
Entrez GeneID
1965Protein Accession#
P05198Gene Name
EIF2S1
Gene Alias
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A
Gene Description
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Omim ID
603907Gene Ontology
HyperlinkGene Summary
The translation initiation factor eIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, eIF2, and GTP. eIF2 is composed of 3 nonidentical subunits, alpha (36 kD), beta (38 kD, MIM 603908), and gamma (52 kD, MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of eIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM
Other Designations
eIF-2-alpha|eukaryotic translation initiation factor 2, subunit 1 (alpha, 35kD )
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Interactome
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Disease
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