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CFL1/CFL2 (phospho Y88) polyclonal antibody

  • Catalog # : PAB25901
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of CFL1/CFL2.
  • Immunogen:
  • Synthetic phosphopeptide corresponding to residues surrounding Y88 of human CFL1/CFL2.
  • Sequence:
  • A-T-Yp-E-T
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 19
  • Reactivity:
  • Human, Mouse, Rat
  • Form:
  • Liquid
  • Purification:
  • Affinity chromatography
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CFL1/CFL2 (phospho Y88) polyclonal antibody (Cat # PAB25901).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 1072
  • Protein Accession#:
  • P23528 (Gene ID : 1072);Q9Y281 (Gene ID : 1073)
  • Gene Name:
  • CFL1
  • Gene Alias:
  • CFL
  • Gene Description:
  • cofilin 1 (non-muscle)
  • Gene Summary:
  • Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM
  • Other Designations:
  • -
  • Gene Information
  • Entrez GeneID:
  • 1073
  • Protein Accession#:
  • P23528 (Gene ID : 1072);Q9Y281 (Gene ID : 1073)
  • Gene Name:
  • CFL2
  • Gene Alias:
  • NEM7
  • Gene Description:
  • cofilin 2 (muscle)
  • Gene Summary:
  • This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq
  • Other Designations:
  • cofilin 2
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