CFL1/CFL2 (phospho Y88) polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CFL1/CFL2 (phospho Y88) polyclonal antibody (Cat # PAB25901).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of CFL1/CFL2.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y88 of human CFL1/CFL2.
Sequence
A-T-Yp-E-T
Host
Rabbit
Theoretical MW (kDa)
19
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CFL1/CFL2 (phospho Y88) polyclonal antibody (Cat # PAB25901). -
Gene Info — CFL1
Entrez GeneID
1072Protein Accession#
P23528 (Gene ID : 1072);Q9Y281 (Gene ID : 1073)Gene Name
CFL1
Gene Alias
CFL
Gene Description
cofilin 1 (non-muscle)
Omim ID
601442Gene Ontology
HyperlinkGene Summary
Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM
Other Designations
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Gene Info — CFL2
Entrez GeneID
1073Protein Accession#
P23528 (Gene ID : 1072);Q9Y281 (Gene ID : 1073)Gene Name
CFL2
Gene Alias
NEM7
Gene Description
cofilin 2 (muscle)
Gene Ontology
HyperlinkGene Summary
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
cofilin 2
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Interactome
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Pathway
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Disease
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