GRB10 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of GRB10 in SK-N-SH cell lysate with GRB10 polyclonal antibody (Cat # PAB25795) at (lane 1) 1 and (lane 2) 2 ug/mL.
Immunofluorescence
Immunofluorescence analysis of GRB10 in rat brain with GRB10 polyclonal antibody (Cat # PAB25795) at 20 ug/mL.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRB10.
Immunogen
A synthetic peptide corresponding to 17 amino acids at C-terminus of human GRB10.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
At least three isoforms of GRB10 are known to exist; this antibody will detect all three isoforms.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
Immunofluorescence (20 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of GRB10 in SK-N-SH cell lysate with GRB10 polyclonal antibody (Cat # PAB25795) at (lane 1) 1 and (lane 2) 2 ug/mL.Immunofluorescence
Immunofluorescence analysis of GRB10 in rat brain with GRB10 polyclonal antibody (Cat # PAB25795) at 20 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GRB10
Entrez GeneID
2887Protein Accession#
NP_005302Gene Name
GRB10
Gene Alias
GRB-IR, Grb-10, IRBP, KIAA0207, MEG1, RSS
Gene Description
growth factor receptor-bound protein 10
Omim ID
601523Gene Ontology
HyperlinkGene Summary
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
GRB10 adaptor protein|insulin receptor-binding protein Grb-IR|maternally expressed gene 1
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Interactome
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Disease
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