UPK1B polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of UPK1B.
Immunogen
A synthetic peptide corresponding to 17 amino acids at internal region of human UPK1B.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
At least two isoforms of UPK1B are known to exist; this antibody will recognize both isoforms. UPK1B antibody is predicted to not cross-react with other tetraspanin protein family members.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (0.5-1 ug/mL)
Immunohistochemistry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of UPK1B in mouse bladder tissue with UPK1B polyclonal antibody (Cat # PAB25730) at 0.5 ug/mL in (lane 1) the absence and (lane 2) the presence of blocking peptide.Immunohistochemistry
Immunohistochemical analysis of UPK1B in human bladder tissue with UPK1B polyclonal antibody (Cat # PAB25730) at 5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — UPK1B
Entrez GeneID
7348Protein Accession#
NP_008883Gene Name
UPK1B
Gene Alias
TSPAN20, UPIB, UPK1
Gene Description
uroplakin 1B
Omim ID
602380Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq
Other Designations
tetraspan
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