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VKORC1 polyclonal antibody

  • Catalog # : PAB25694
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of VKORC1.
  • Immunogen:
  • A synthetic peptide corresponding to 15 amino acids at N-terminus of human VKORC1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Purification:
  • Peptide affinity purification
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    Immunohistochemistry (2.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of VKORC1 in A-549 cell lysate with VKORC1 polyclonal antibody (Cat # PAB25694) at 1 ug/mL.
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical analysis of VKORC1 in human lung tissue with VKORC1 polyclonal antibody (Cat # PAB25694) at 2.5 ug/mL.
  • ELISA
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • VKORC1
  • Gene Alias:
  • EDTP308,FLJ00289,IMAGE3455200,MGC2694,MST134,MST576,VKCFD2,VKOR
  • Gene Description:
  • vitamin K epoxide reductase complex, subunit 1
  • Gene Summary:
  • Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq
  • Other Designations:
  • phylloquinone epoxide reductase,vitamin K dependent clotting factors deficiency 2,vitamin K1 epoxide reductase (warfarin-sensitive)
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