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Last updated: 2017/6/25

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CASP3 polyclonal antibody

  • Catalog # : PAB25662
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of CASP3.
  • Immunogen:
  • A synthetic peptide corresponding to 17 amino acids at internal region of human CASP3.
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 30
  • Reactivity:
  • Human
  • Specificity:
  • At least two isoforms of Caspase-3 are known to exist.
  • Form:
  • Liquid
  • Purification:
  • Peptide affinity purification
  • Concentration:
  • 1 mg/mL
  • Isotype:
  • IgG
  • Recommend Usage:
  • Immunohistochemistry (5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.05% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical analysis of CASP3 in human tonsil tissue with CASP3 polyclonal antibody (Cat # PAB25662) at 5 ug/mL.
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 836
  • Gene Name:
  • CASP3
  • Gene Alias:
  • CPP32,CPP32B,SCA-1
  • Gene Description:
  • caspase 3, apoptosis-related cysteine peptidase
  • Gene Summary:
  • This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000165054,PARP cleavage protease,SREBP cleavage activity 1,Yama,apopain,caspase 3,caspase 3, apoptosis-related cysteine protease,cysteine protease CPP32,procaspase3
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