CDH5 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of CDH5 polyclonal antibody (Cat # PAB2565) in 293 cell line lysates (35 ug/lane). CDH5 (arrow) was detected using the purified polyclonal antibody.
Flow Cytometry
Flow cytometric analysis of 293 cells using CDH5 polyclonal antibody (Cat # PAB2565)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDH5.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human CDH5.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Flow cytometry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CDH5 polyclonal antibody (Cat # PAB2565) in 293 cell line lysates (35 ug/lane). CDH5 (arrow) was detected using the purified polyclonal antibody.Flow Cytometry
Flow cytometric analysis of 293 cells using CDH5 polyclonal antibody (Cat # PAB2565)(bottom histogram) compared to a negative control cell (top histogram).
FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. -
Gene Info — CDH5
Entrez GeneID
1003Protein Accession#
NP_001786;P33151Gene Name
CDH5
Gene Alias
7B4, CD144, FLJ17376
Gene Description
cadherin 5, type 2 (vascular endothelium)
Omim ID
601120Gene Ontology
HyperlinkGene Summary
This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq
Other Designations
7B4 antigen|VE-cadherin|cadherin 5, type 2|cadherin 5, type 2, VE-cadherin (vascular epithelium)|cd144 antigen|endothelial-specific cadherin|vascular endothelial cadherin
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Interactome
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Pathway
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Disease
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Publication Reference
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Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.
Ali J, Liao F, Martens E, Muller WA.
Microcirculation 1997 Jun; 4(2):267.
Application：WB-Ce, Human, HUVEC cells.
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Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue.
Suzuki S, Sano K, Tanihara H.
Cell Regulation 1991 Apr; 2(4):261.
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Vascular endothelial cadherin (VE-cadherin): cloning and role in endothelial cell-cell adhesion.
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