BCL6 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of BCL6 in rat lung tissue with BCL6 polyclonal antibody (Cat # PAB25644) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BCL6.
Immunogen
A synthetic peptide corresponding to 18 amino acids at internal region of human BCL6.
Host
Rabbit
Theoretical MW (kDa)
78
Reactivity
Human, Mouse, Rat
Specificity
Three alternatively spliced transcript variants have been observed.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of BCL6 in rat lung tissue with BCL6 polyclonal antibody (Cat # PAB25644) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.Enzyme-linked Immunoabsorbent Assay
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Gene Info — BCL6
Entrez GeneID
604Protein Accession#
NP_001124317Gene Name
BCL6
Gene Alias
BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Gene Description
B-cell CLL/lymphoma 6
Omim ID
109565Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq
Other Designations
B-cell lymphoma 6 protein|B-cell lymphoma 6 protein transcript|cys-his2 zinc finger transcription factor|lymphoma-associated zinc finger gene on chromosome 3|zinc finger protein 51|zinc finger transcription factor BCL6S
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Interactome
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Disease
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