Western blot analysis of BCL6 in rat lung tissue with BCL6 polyclonal antibody (Cat # PAB25644) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq
Other Designations:
B-cell lymphoma 6 protein,B-cell lymphoma 6 protein transcript,cys-his2 zinc finger transcription factor,lymphoma-associated zinc finger gene on chromosome 3,zinc finger protein 51,zinc finger transcription factor BCL6S