KEAP1 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KEAP1.
Immunogen
A synthetic peptide corresponding to 19 amino acids at C-terminus of human KEAP1.
Host
Rabbit
Theoretical MW (kDa)
69
Reactivity
Human, Mouse, Rat
Specificity
At least two isoforms of KEAP1 are known to exist.
Form
Liquid
Purification
Peptide affinity purification
Concentration
1 mg/mL
Isotype
IgG
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of KEAP1 in human lung tissue with KEAP1 polyclonal antibody (Cat # PAB25620) at (1) 1 and (2) 2 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KEAP1
Entrez GeneID
9817Protein Accession#
NP_987096Gene Name
KEAP1
Gene Alias
INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
Gene Description
kelch-like ECH-associated protein 1
Omim ID
606016Gene Ontology
HyperlinkGene Summary
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq
Other Designations
cytosolic inhibitor of Nrf2
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Interactome
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Pathway
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Disease
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Publication Reference
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Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways.
Jeong H, Liu Y, Kim HS.
Experimental Gerontology 2017 May; 95:16.
Application:WB-Ti, Mouse, Mouse liver.
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Dried plum and chokeberry ameliorate d-galactose-induced aging in mice by regulation of Pl3k/Akt-mediated Nrf2 and Nf-kB pathways.
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