ADRA2C polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ADRA2C.
Immunogen
A synthetic peptide corresponding to 18 amino acids at 3rd cytoplasmic domain of human ADRA2C.
Host
Rabbit
Reactivity
Human, Monkey
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (12 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed, paraffin-embedded human artery, smooth muscle tissue after heat-induced antigen retrieval.
Using ADRA2C polyclonal antibody (Cat # PAB25565). -
Gene Info — ADRA2C
Entrez GeneID
152Gene Name
ADRA2C
Gene Alias
ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Gene Description
adrenergic, alpha-2C-, receptor
Omim ID
104250Gene Ontology
HyperlinkGene Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq
Other Designations
alpha-2C-adrenergic receptor|alpha2-AR-C4
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