HTR2C polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HTR2C.
Immunogen
A synthetic peptide corresponding to 16 amino acids at 3rd cytoplasmic domain of human HTR2C.
Host
Rabbit
Reactivity
Human, Monkey
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Form
Liquid
Purification
Immunoaffinity chromatography
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2.6 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of formalin-fixed, paraffin-embedded human pancreas, ganglion and schwann cells tissue after heat-induced antigen retrieval.
Using HTR2C polyclonal antibody (Cat # PAB25546). -
Gene Info — HTR2C
Entrez GeneID
3358Gene Name
HTR2C
Gene Alias
5-HT2C, 5-HTR2C, HTR1C
Gene Description
5-hydroxytryptamine (serotonin) receptor 2C
Omim ID
312861Gene Ontology
HyperlinkGene Summary
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq
Other Designations
5-hydroxytryptamine receptor 2C|OTTHUMP00000023868|OTTHUMP00000023869|serotonin 5-HT-2C receptor|serotonin receptor 2C
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