CRIM1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CRIM1.
Immunogen
A synthetic peptide corresponding to C-terminus of human CRIM1.
Host
Rabbit
Reactivity
Human
Specificity
CRIM1 antibody is human reactive. CRIM1 antibody is predicted to not cross-react with CRIM2.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of Jurkat cell lysate with CRIM1 polyclonal antibody (Cat # PAB25500) at 1 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — CRIM1
Entrez GeneID
51232Protein Accession#
NP_057525Gene Name
CRIM1
Gene Alias
MGC138194, S52
Gene Description
cysteine rich transmembrane BMP regulator 1 (chordin-like)
Omim ID
606189Gene Ontology
HyperlinkGene Summary
Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed Sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM
Other Designations
cysteine-rich motor neuron 1|cysteine-rich repeat-containing protein S52
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