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SHANK3 polyclonal antibody

  • Catalog # : PAB25490
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of SHANK3.
  • Immunogen:
  • A synthetic peptide corresponding to internal region of human SHANK3.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse
  • Specificity:
  • At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.
  • Form:
  • Liquid
  • Purification:
  • Affinity purification
  • Concentration:
  • 1 mg/mL
  • Recommend Usage:
  • Western Blot (1 ug/mL)
    Immunohistochemistry (2.5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C for three months. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of NIH/3T3 cell lysate with SHANK3 polyclonal antibody (Cat # PAB25490) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.
  • Immunohistochemistry
  • Immunohistochemistry
  • Immunohistochemical anyalysis of human brain tissue with SHANK3 polyclonal antibody (Cat # PAB25490) at 2.5 ug/mL.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • SHANK3
  • Gene Alias:
  • DEL22q13.3,KIAA1650,PROSAP2,PSAP2,SPANK-2
  • Gene Description:
  • SH3 and multiple ankyrin repeat domains 3
  • Gene Summary:
  • This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD) which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene are a major causitive factor in the neurological symptoms of 22q13.3 deletion syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq
  • Other Designations:
  • proline rich synapse associated protein 2,proline-rich synapse-associated protein 2,shank postsynaptic density protein
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