SHANK3 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SHANK3.
Immunogen
A synthetic peptide corresponding to internal region of human SHANK3.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
At least three alternatively spliced transcript isoforms of SHANK3 are known to exist.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1 ug/mL)
Immunohistochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of NIH/3T3 cell lysate with SHANK3 polyclonal antibody (Cat # PAB25490) at 1 ug/mL in (1) the absence and (2) the presence of blocking peptide.Immunohistochemistry
Immunohistochemical anyalysis of human brain tissue with SHANK3 polyclonal antibody (Cat # PAB25490) at 2.5 ug/mL.Enzyme-linked Immunoabsorbent Assay
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Gene Info — SHANK3
Entrez GeneID
85358Protein Accession#
NP_001073889Gene Name
SHANK3
Gene Alias
DEL22q13.3, KIAA1650, PROSAP2, PSAP2, SPANK-2
Gene Description
SH3 and multiple ankyrin repeat domains 3
Gene Ontology
HyperlinkGene Summary
This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD) which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene are a major causitive factor in the neurological symptoms of 22q13.3 deletion syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq
Other Designations
proline rich synapse associated protein 2|proline-rich synapse-associated protein 2|shank postsynaptic density protein
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Interactome
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Disease
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