KCNIP3 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human KCNIP3 with C-terminal MYC tag probed with KCNIP3 polyclonal antibody (Cat # PAB25445) (1 ug/mL) in Lane 1 and probed with anti-MYC Tag (1/1000) in lane 3. Mock-transfected HEK293 probed with KCNIP3 polyclonal antibody (Cat # PAB25445) (1 mg/mL) in Lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of KCNIP3.
Immunogen
A synthetic peptide corresponding to internal region of human KCNIP3.
Sequence
CHTPLSKKEGIK
Host
Goat
Theoretical MW (kDa)
30
Reactivity
Human
Specificity
This antibody is expected to recognize isoform 1 (NP_038462.1) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.02% sodium azide, 0.5% BSA)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
HEK293 lysate (10 ug protein in RIPA buffer) overexpressing human KCNIP3 with C-terminal MYC tag probed with KCNIP3 polyclonal antibody (Cat # PAB25445) (1 ug/mL) in Lane 1 and probed with anti-MYC Tag (1/1000) in lane 3. Mock-transfected HEK293 probed with KCNIP3 polyclonal antibody (Cat # PAB25445) (1 mg/mL) in Lane 2. Primary incubations were for 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — KCNIP3
Entrez GeneID
30818Protein Accession#
NP_038462.1Gene Name
KCNIP3
Gene Alias
CSEN, DREAM, KCHIP3, MGC18289
Gene Description
Kv channel interacting protein 3, calsenilin
Omim ID
604662Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq
Other Designations
A-type potassium channel modulatory protein 3|DRE-antagonist modulator|Kv channel interacting protein 3|calsenilin, presenilin-binding protein, EF hand transcription factor|potassium channel interacting protein 3
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Interactome
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Disease
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