HDAC5 (phospho S498) polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extract from NIH/3T3 cells using HDAC5 (phospho S498) polyclonal antibody (Cat # PAB25430).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using HDAC5 (phospho S498) polyclonal antibody (Cat # PAB25430).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of HDAC5.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding S498 of human HDAC5.
Sequence
T-Q-Sp-S-P
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extract from NIH/3T3 cells using HDAC5 (phospho S498) polyclonal antibody (Cat # PAB25430).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using HDAC5 (phospho S498) polyclonal antibody (Cat # PAB25430). -
Gene Info — HDAC5
Entrez GeneID
10014Protein Accession#
Q9UQL6Gene Name
HDAC5
Gene Alias
FLJ90614, HD5, NY-CO-9
Gene Description
histone deacetylase 5
Omim ID
605315Gene Ontology
HyperlinkGene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
antigen NY-CO-9
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Interactome
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Disease
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