QKI polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with QKI polyclonal antibody (Cat # PAB2543) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of QKI.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human QKI.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human brain tissue reacted with QKI polyclonal antibody (Cat # PAB2543) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. -
Gene Info — QKI
Entrez GeneID
9444Protein Accession#
NP_996736;Q96PU8Gene Name
QKI
Gene Alias
DKFZp586I0923, Hqk, QK, QK1, QK3
Gene Description
quaking homolog, KH domain RNA binding (mouse)
Omim ID
609590Gene Ontology
HyperlinkGene Summary
QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]). QKI proteins regulate RNA splicing, export of target RNAs from the nucleus, translation of proteins, and RNA stability (Lauriat et al., 2008 [PubMed 17918747]).[supplied by OMIM
Other Designations
OTTHUMP00000017581|OTTHUMP00000017582|OTTHUMP00000017583|RNA binding protein HQK|homolog of mouse quaking QKI (KH domain RNA binding protein)|quaking homolog, KH domain RNA binding
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Interactome
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Disease
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Publication Reference
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Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.
Zhao L, Tian D, Xia M, Macklin WB, Feng Y.
Journal of Neuroscience 2006 Nov; 26(44):11278.
Application：WB, Mouse, Mouse cerebellum.
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The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia.
Haroutunian V, Katsel P, Dracheva S, Davis KL.
The American Journal of Psychiatry 2006 Oct; 163(10):1834.
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Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.
Aberg K, Saetre P, Jareborg N, Jazin E.
PNAS 2006 May; 103(19):7482.
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Rescuing qkV dysmyelination by a single isoform of the selective RNA-binding protein QKI.
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