VAV1 (phospho Y174) polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of VAV1.
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding Y174 of human VAV1.
Sequence
E-I-Yp-E-D
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity purification
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of the extracts from Jurkat cells using VAV1 (phospho Y174) polyclonal antibody (Cat # PAB25422). -
Gene Info — VAV1
Entrez GeneID
7409Protein Accession#
P15498Gene Name
VAV1
Gene Alias
VAV
Gene Description
vav 1 guanine nucleotide exchange factor
Omim ID
164875Gene Ontology
HyperlinkGene Summary
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. [provided by RefSeq
Other Designations
oncogene vav|vav 1 oncogene|vav proto-oncogene
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Interactomes
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