PADI4 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of PADI4.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PADI4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of PADI4 polyclonal antibody (Cat # PAB2519) in 293 cell line lysate. PAD4 (arrow) was detected using the purified polyclonal antibody. -
Gene Info — PADI4
Entrez GeneID
23569Protein Accession#
NP_036519;Q9UM07Gene Name
PADI4
Gene Alias
PAD, PAD4, PADI5, PDI4, PDI5
Gene Description
peptidyl arginine deiminase, type IV
Gene Ontology
HyperlinkGene Summary
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq
Other Designations
HL-60 PAD|OTTHUMP00000002482|PADI-H protein|peptidyl arginine deiminase, type V|protein-arginine deiminase
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Interactome
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Disease
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Publication Reference
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Comparison of enzymatic properties between hPADI2 and hPADI4.
Nakayama-Hamada M, Suzuki A, Kubota K, Takazawa T, Ohsaka M, Kawaida R, Ono M, Kasuya A, Furukawa H, Yamada R, Yamamoto K.
Biochemical and Biophysical Research Communications 2005 Feb; 327(1):192.
Application:IHC-P, Human, Human rheumatoid arthritis synovium.
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Human PAD4 regulates histone arginine methylation levels via demethylimination.
Wang Y, Wysocka J, Sayegh J, Lee YH, Perlin JR, Leonelli L, Sonbuchner LS, McDonald CH, Cook RG, Dou Y, Roeder RG, Clarke S, Stallcup MR, Allis CD, Coonrod SA.
Science 2004 Sep; 306(5694):279.
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A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population.
Barton A, Bowes J, Eyre S, Spreckley K, Hinks A, John S, Worthington J.
Arthritis and Rheumatism 2004 Apr; 50(4):1117.
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Comparison of enzymatic properties between hPADI2 and hPADI4.
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