DEFA3 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue using DEFA3 polyclonal antibody (Cat # PAB25148).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DEFA3.
Immunogen
A synthetic peptide corresponding to DEFA3.
Host
Rabbit
Reactivity
Human
Specificity
DEFA3 polyclonal antibody detects endogenous levels of DEFA3 protein.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue using DEFA3 polyclonal antibody (Cat # PAB25148). -
Gene Info — DEFA3
Entrez GeneID
1668Gene Name
DEFA3
Gene Alias
DEF3, HNP-3, HNP3, HP-3
Gene Description
defensin, alpha 3, neutrophil-specific
Omim ID
604522Gene Ontology
HyperlinkGene Summary
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from defensin, alpha 1 by only one amino acid. [provided by RefSeq
Other Designations
defensin 3, neutrophil-specific|defensin, alpha 3|neutrophil peptide 3
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Interactome
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Disease
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Publication Reference
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Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma.
Yukie Suzuki, Tatsuyuki Takadate, Masamichi Mizuma, Hiroki Shima, Takashi Suzuki, Tomoyoshi Tachibana, Mitsuhiro Shimura, Tatsuo Hata, Masahiro Iseki, Kei Kawaguchi, Takeshi Aoki, Hiroki Hayashi, Takanori Morikawa, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Kazuhiko Igarashi, Michiaki Unno.
PLoS One 2020 Jul; 15(7):e0235904.
Application：IHC-P, Human, Human pancreatic ductal adenocarcinoma.
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Stromal expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma.
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