ICMT polyclonal antibody
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More Files
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Western Blot (Cell lysate)
The ICMT polyclonal antibody (Cat # PAB2513) is used in Western blot to detect ICMT in T-47D (left) and SK-BR-3 (right) cell lysates.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ICMT.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ICMT.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The ICMT polyclonal antibody (Cat # PAB2513) is used in Western blot to detect ICMT in T-47D (left) and SK-BR-3 (right) cell lysates. -
Gene Info — ICMT
Entrez GeneID
23463Protein Accession#
NP_036537;O60725Gene Name
ICMT
Gene Alias
HSTE14, MGC39955, MST098, MSTP098, PCCMT, PCMT, PPMT
Gene Description
isoprenylcysteine carboxyl methyltransferase
Omim ID
605851Gene Ontology
HyperlinkGene Summary
This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000001381|prenylated protein carboxyl methyltransferase|prenylcysteine carboxyl methyltransferase|protein-S isoprenylcysteine O-methyltransferase
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Interactome
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Disease
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Publication Reference
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG.
The Journal of Clinical Investigation 2004 Feb; 113(4):539.
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Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells.
Van Dessel GA, De Busser HM, Lagrou AR.
The International Journal of Biochemistry & Cell Biology 2002 May; 34(5):477.
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Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.
Ahmad M, Zhang Y, Zhang Y, Papharalambus C, Alexander RW.
Arteriosclerosis, Thrombosis, and Vascular Biology 2002 May; 22(5):759.
Application：WB-Ce, Human, HAECs.
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
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