MLH3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of K-562 cell extracts with MLH3 polyclonal antibody (Cat # PAB25016).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MLH3.
Immunogen
A synthetic peptide corresponding to MLH3.
Host
Rabbit
Theoretical MW (kDa)
164
Reactivity
Human
Specificity
MLH3 polyclonal antibody detects endogenous levels of MLH3.
Form
Liquid
Purification
Antigen affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of K-562 cell extracts with MLH3 polyclonal antibody (Cat # PAB25016).Immunohistochemistry
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Gene Info — MLH3
Entrez GeneID
27030Gene Name
MLH3
Gene Alias
HNPCC7, MGC138372
Gene Description
mutL homolog 3 (E. coli)
Gene Ontology
HyperlinkGene Summary
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq
Other Designations
DNA mismatch repair protein MLH3|mutL homolog 3
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Interactome
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Pathway
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Disease
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